Directions

We focus on measures and modifications of cortical excitability by techniques that we hope will improve the treatment and understanding of neurological disorders, particularly the epilepsies and neurodevelopmental disabilities.

Novel Therapeutics

Our researchers are developing gene therapies for a range of rare pediatric syndromes such as succinic semialdehyde dehydrogenase deficiency (SSADHD) and SLC6A1 neurodevelopmetal disorder (SLC6A1). In parallel, we are testing and developing novel anti-seizure compounds such as activators of the Kv3.1 voltage-gated potassium channel.

Biomarkers in Epilepsy, Autism, and Other Neurological Disorders

We are measuring brain function by EEG and by transcranial magnetic stimulation (TMS) to improve detection of either excitation:inhibition imbalance, or its restoration by gene and drug therapy.

Therapeutic Noninvasive Brain Stimiulation

We investigate how targeted neuromodulation approaches—such as TMS and transcranial direct current stimulation (tDCS) can safely and effectively alter brain networks, particularly for pursposes of seizure suppression.